A novel calcium signaling pathway targets the c-fos intragenic transcriptional pausing site.

@article{Coulon1999ANC,
  title={A novel calcium signaling pathway targets the c-fos intragenic transcriptional pausing site.},
  author={Vincent Coulon and Jean Luc Veyrune and N Tourkine and Annick Vi{\'e} and R. A. Hipskind and Jean Marie Blanchard},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 43},
  pages={30439-46}
}
In many cell types, increased intracellular calcium gives rise to a robust induction of c-fos gene expression. Here we show that in mouse Ltk(-) fibroblasts, calcium ionophore acts in synergy with either cAMP or PMA to strongly induce the endogenous c-fos gene. Run-on analysis shows that this corresponds to a substantial increase in active polymerases on downstream gene sequences, i.e. relief of an elongation block by calcium. Correspondingly a chimeric gene, in which the human metallothionein… CONTINUE READING

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