A novel borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region.

@article{Daito2011ANB,
  title={A novel borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region.},
  author={Takuji Daito and Kan Fujino and Tomoyuki Honda and Yusuke Matsumoto and Yohei Watanabe and Keizo Tomonaga},
  journal={Journal of virology},
  year={2011},
  volume={85 23},
  pages={12170-8}
}
Borna disease virus (BDV), a nonsegmented, negative-strand RNA virus, infects a wide variety of mammalian species and readily establishes a long-lasting, persistent infection in brain cells. Therefore, this virus could be a promising candidate as a novel RNA virus vector enabling stable gene expression in the central nervous system (CNS). Previous studies demonstrated that the 5' untranslated region of the genome is the only site for insertion and expression of a foreign gene. In this study, we… CONTINUE READING
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