A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine.

  title={A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine.},
  author={Kazunori Yamamoto and Kee Dong Yoon and Keiko Ueda and Masaru Hashimoto and Janet R Sparrow},
  journal={Investigative ophthalmology & visual science},
  volume={52 12},
PURPOSE Fluorescent bisretinoid compounds accumulate in retinal pigment epithelial (RPE) cells as a consequence of two processes: random reactions of vitamin A aldehyde in photoreceptor cell outer segments, and phagocytosis of discarded photoreceptor outer segment discs by RPE. The formation of bisretinoid is accentuated in some forms of retinal degeneration. The detection of a novel bisretinoid fluorophore that is a conjugate of all-trans-retinal and glycerophosphoethanolamine is reported… CONTINUE READING


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