A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.

@article{ZangemeisterWittke2000ANB,
  title={A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.},
  author={Uwe Zangemeister-Wittke and Si{\^a}n H. Leech and Robert A. Olie and Ana Paula Sim{\~o}es-W{\"u}st and Oliver Gautschi and Gerd H. Luedke and Francois Natt and Robert H{\"a}ner and Pierre Dr Martin and Janet A. Hall and Carlo M. Nalin and Rolf Arno Stahel},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 6},
  pages={
          2547-55
        }
}
Bcl-2 and Bcl-xL are inhibitors of apoptosis frequently overexpressed in solid tumors. The bcl-2 and bcl-xL mRNAs share a region of homology comprising nucleotides 605-624 and 687-706, respectively, which differs by only three nucleotides. This sequence does not occur in the proapoptotic splice variant bcl-xS. To test the possibility that oligonucleotides targeting this region have the potential to down-regulate bcl-2 and bcl-xL expression simultaneously, three 2'-O-methoxy-ethoxy-modified… CONTINUE READING

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