A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex.

@article{Fodor1995ANB,
  title={A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex.},
  author={William L. Fodor and Scott A. Rollins and Edward R. Guilmette and Eva Setter and Stephen P. Squinto},
  journal={Journal of immunology},
  year={1995},
  volume={155 9},
  pages={4135-8}
}
Human cells express cell surface complement regulatory molecules that inhibit the activity of the C3/C5 convertases (DAF, MCP, CR1) or inhibit the membrane attack complex (CD59). A single molecule that inhibits both the convertase activity and formation of the membrane attack complex has never been characterized. To this end, we have developed two reciprocal chimeric complement inhibitors (CD, NH2-CD59-DAF-GPI; and DC, NH2-DAF-CD59-GPI) that contain the functional domains of decay accelerating… CONTINUE READING

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