A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits.

@article{Morales1995ANB,
  title={A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits.},
  author={Michael J. Morales and Robert C. Castellino and Anne L. Crews and Randall L. Rasmusson and Harold C. Strauss},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 11},
  pages={
          6272-7
        }
}
Voltage-gated potassium channel beta subunits are cytoplasmic proteins that co-purify with the pore-forming alpha subunits. One of these subunits, Kv beta 1 from rat brain, was previously demonstrated to increase the rate of inactivation of Kv1.1 and Kv1.4 when co-expressed in Xenopus oocytes. We have cloned and characterized a novel voltage-gated K+ channel beta subunit. The cDNA, designated Kv beta 3, has a 408-amino acid open reading frame. It possesses a unique 79-amino acid N-terminal… CONTINUE READING

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The Cardiac Ion Channels

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Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
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