A novel autosomal dominant spinocerebellar ataxia (SCA22) linked to chromosome 1p21-q23.

@article{Chung2003ANA,
  title={A novel autosomal dominant spinocerebellar ataxia (SCA22) linked to chromosome 1p21-q23.},
  author={M Y Chung and Yi-chun Lu and Nai-Chia Cheng and Bing-Wen Soong},
  journal={Brain : a journal of neurology},
  year={2003},
  volume={126 Pt 6},
  pages={1293-9}
}
The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of disorders. Ten responsible genes have been identified for spinocerebellar ataxia types SCA1, SCA2, SCA3, SCA6, SCA7, SCA8, SCA10, SCA12 and SCA17, and dentatorubral pallidoluysian atrophy (DRPLA). The mutation is caused by an expansion of a CAG, CTG or ATTCT repeat sequence of these genes. Six additional loci, SCA4, SCA5, SCA11, SCA13, SCA14 and SCA16 have also been mapped… CONTINUE READING