A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.

@article{Tsuji1997ANA,
  title={A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.},
  author={Masaaki Tsuji and Yasuharu Ezumi and Maya Arai and Hiroshi Takayama},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 38},
  pages={23528-31}
}
The mechanism by which occupancy of collagen receptors is coupled to platelet activation has been uncertain. Our group previously demonstrated that glycoprotein (GP) VI, an uncharacterized platelet membrane protein, is specifically required for collagen-platelet interaction leading to activation of protein-tyrosine kinase Syk. Since collagen stimulation of platelets has recently been found to induce tyrosine phosphorylation of Fc receptor (FcR) gamma-chain, a signal-generating subunit of FcR… CONTINUE READING
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