A novel assay for analysis of the regulation of the function of human osteoclasts

@article{Kirstein2006ANA,
  title={A novel assay for analysis of the regulation of the function of human osteoclasts},
  author={Barrie Kirstein and Urszula B Grabowska and Bertil Samuelsson and Masahiro Shiroo and Timothy John Chambers and Karen Fuller},
  journal={Journal of Translational Medicine},
  year={2006},
  volume={4},
  pages={45 - 45}
}
Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo. It has recently become possible to generate human osteoclasts in vitro, by incubation of peripheral blood mononuclear cells (PBMCs) in macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). However, the assays at present available do not distinguish clearly between the distinct effects of… CONTINUE READING

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