A novel approach to recovery of function of mutant proteins by slowing down translation.

@article{Meriin2012ANA,
  title={A novel approach to recovery of function of mutant proteins by slowing down translation.},
  author={Anatoli B Meriin and Martin Mense and Jeff D. Colbert and Feng Liang and Hermann Bihler and Nava Zaarur and Kenneth L. Rock and Michael Yu Sherman},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 41},
  pages={
          34264-72
        }
}
Protein homeostasis depends on a balance of translation, folding, and degradation. Here, we demonstrate that mild inhibition of translation results in a dramatic and disproportional reduction in production of misfolded polypeptides in mammalian cells, suggesting an improved folding of newly synthesized proteins. Indeed, inhibition of translation elongation, which slightly attenuated levels of a copepod GFP mutant protein, significantly enhanced its function. In contrast, inhibition of… CONTINUE READING

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