A novel approach to protein-protein interaction: complex formation between the p53 tumor suppressor and the HIV Tat proteins.

@article{Longo1995ANA,
  title={A novel approach to protein-protein interaction: complex formation between the p53 tumor suppressor and the HIV Tat proteins.},
  author={Filomena Longo and Maria A Marchetti and Luisa Castagnoli and Piero Augusto Battaglia and Franca Gigliani},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={206 1},
  pages={326-34}
}
By using a novel genetic approach, based on the properties of lambda cl repressor, we demonstrate that the HIV-1 Tat protein specifically interacts with the human p53 protein via the p53 O2 dimerization domain. By random and site-specific mutagenesis, we also identify the residues in Tat and O2 peptides which are involved in this interaction. Two alternative biological consequences are expected to result from Tat-p53 interaction: (i) Tat-O2 interaction inactivates p53 regulation function, thus… CONTINUE READING

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