A novel approach to identify antigens recognized by CD4 T cells using complement-opsonized bacteria expressing a cDNA library

@article{Corput2005ANA,
  title={A novel approach to identify antigens recognized by CD4 T cells using complement-opsonized bacteria expressing a cDNA library},
  author={L van de Corput and Pascal Chaux and Edith D. van der Meijden and Eienne De Plaen and J H Frederik Falkenburg and Pierre van der Bruggen},
  journal={Leukemia},
  year={2005},
  volume={19},
  pages={279-285}
}
In patients with hematological malignancies receiving HLA-matched stem cell transplantation, T cells specific for minor histocompatibility antigens play a major role in graft rejection, induction of graft-versus-host disease and beneficial graft-versus-leukemia reactivity. Several human minor histocompatibility antigens recognized by T cells have been identified, but only two are presented by HLA class II molecules. In search of an efficient approach to identify antigenic peptides processed… CONTINUE READING