A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.

@article{Ollerstam2007ANA,
  title={A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.},
  author={Anna Ollerstam and Anna H Persson and Sandra A. G. Visser and J. Magnus Fredriksson and Tomas Forsberg and Lars B. Nilsson and G. Monica Eklund and Stig Johan Wiklund and Johan Gabrielsson and G{\"o}ran Duker and Ahmad Al-Saffar},
  journal={Journal of pharmacological and toxicological methods},
  year={2007},
  volume={55 1},
  pages={35-48}
}
INTRODUCTION Drug-induced QT interval prolongation may lead to ventricular arrhythmias. The aim of the study was to optimize QT interval data processing to quantify drug-induced QT interval prolongation in the telemetry instrumented conscious dog model. METHODS The test substances cisapride, dofetilide, haloperidol, and terfenadine and corresponding vehicles were given to male and female beagle dogs during two consecutive 90-min intravenous infusions. Cardiovascular parameters were recorded… CONTINUE READING
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