A novel approach for the production of monoclonal antibodies using infectious vaccinia virus recombinants.

We describe a novel approach of producing monoclonal antibodies (MABs) to one specific protein of a virus or other agent consisting of several proteins, without the use of purified antigen in either the immunization or screening phase of the procedure. This method has general application in the production of MABs when the antigen cannot be obtained in a… CONTINUE READING