A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer.

@article{Hu2012ANA,
  title={A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer.},
  author={Yuntao Hu and Laura L. Liu and Bo Lu and Danhong Zhu and Ramiro Magalh{\~a}es Ribeiro and Bruno Lendro Maranh{\~a}o Diniz and P. B. Zablocki Thomas and Ashish K. Ahuja and David R Hinton and Yu-Chong Tai and Sherry T. Hikita and Lincoln V. Johnson and Dennis O Clegg and Biju B Thomas and Mark S. Humayun},
  journal={Ophthalmic research},
  year={2012},
  volume={48 4},
  pages={
          186-91
        }
}
OBJECTIVE To evaluate the feasibility of a new technique for the implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into the subretinal space of retina-degenerate Royal College of Surgeon (RCS) rats. METHODS A platform device was used for the implantation of 4-µm-thick parylene substrates containing a monolayer of human embryonic stem cell-derived RPE (hESC-RPE). Normal Copenhagen rats (n = 6) and RCS rats (n = 5) were used for the study… CONTINUE READING

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