A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling

@article{Yamurlu2004ANA,
  title={A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling},
  author={Aydin Yağmurlu and Burhan Aksu and Meltem Bingol-kologlu and Nurten Renda and Gulcin Altinok and Suat Fitoz and I. Haluk Gokçora and Huseyin Dindar},
  journal={Pediatric Surgery International},
  year={2004},
  volume={20},
  pages={778-782}
}
Using a new class of intracellular 2nd messengers to prevent stricture formation after caustic ingestion, sphingosylphosphorylcholine (SPC) has a wide spectrum of activity in cell growth regulation and signal transduction. Caustic esophageal burns were created with 15% NaOH in an experimental rat model. Control group animals (n=10) had esophageal burns with no treatment, whereas the SPC group (n=10) had esophageal burns gavaged with SPC for 7 days. Efficacy of treatment was assessed in 28 days… CONTINUE READING
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