A novel approach for medical countermeasures to nerve agent poisoning in the guinea-pig.

@article{Wetherell2006ANA,
  title={A novel approach for medical countermeasures to nerve agent poisoning in the guinea-pig.},
  author={Janet R Wetherell and Matthew E. Price and Helen Mumford},
  journal={Neurotoxicology},
  year={2006},
  volume={27 4},
  pages={485-91}
}
This study forms part of a larger programme of work aimed at developing improved medical countermeasures for nerve agent poisoning with less reliance on pretreatment. Therapy with N(6)-cyclopentyladenosine (CPA), physostigmine, hyoscine and HI-6 protected guinea-pigs against the incapacitating and lethal effects of a supralethal challenge of soman (135 microg/kg) when given 1 min after poisoning. CPA, however has well-recognised side effects that are likely to preclude it being licensed for use… CONTINUE READING

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