A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit.

@article{Mejia2010ANA,
  title={A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit.},
  author={Monica A. Mejia and Mari D. Heghinian and Alexandra Busch and Chris J Armishaw and Frank Mar{\'i} and Tanja A Godenschwege},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2010},
  volume={56 8},
  pages={1398-407}
}
Finding compounds that affect neuronal or muscular function is of great interest as potential therapeutic agents for a variety of neurological disorders. Alternative applications for these compounds include their use as molecular probes as well as insecticides. We have developed a bioassay that requires small amounts of compounds and allows for unbiased screening of biological activity in vivo. For this, we paired administering compounds in a non-invasive manner with simultaneous… CONTINUE READING