A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT.

@article{Nikolic2000ANA,
  title={A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT.},
  author={Boris Nikolic and Guiling Zhao and Kirsten A. Swenson and Megan Sykes},
  journal={Blood},
  year={2000},
  volume={96 3},
  pages={1166-72}
}
The treatment of mice with anti-CD4 and anti-CD8 monoclonal antibodies (mAbs) on day -5, plus 3 Gy whole body irradiation (WBI) and 7 Gy thymic irradiation (TI) on day 0, allows fully major-histocompatibility-complex-mismatched allogeneic bone marrow engraftment and the induction of immunologic tolerance. TI is required in this model to overcome… CONTINUE READING