A novel aortic coarctation model for studying hypertension in the pig.

@article{Fossum2003ANA,
  title={A novel aortic coarctation model for studying hypertension in the pig.},
  author={Theresa W. Fossum and Wendy I Baltzer and Matthew W. Miller and M. P. Martin Aguirre and Debbi Whitlock and Phil F. Solter and Lori A Makarski and Michelle M McDonald and Mi-young An and Jay D. Humphrey},
  journal={Journal of investigative surgery : the official journal of the Academy of Surgical Research},
  year={2003},
  volume={16 1},
  pages={35-44}
}
We have developed a reproducible renovascular model of hypertension via a controllable, suprarenal aortic coarctation in the pig. This model has many potential applications, including investigation of the effects of acute hypertension in the conscious animal; identification of cardiac and vascular adaptations to chronic hypertension and their reversal; determining the effect of pharmacologic agents or other interventions on hypertension; and furthering our understanding of the implications of… CONTINUE READING
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