A novel antitumor cyclic hexapeptide (RA-700) obtained from Rubiae radix.


The antitumor activity of a newly obtained cyclic hexapeptide, RA-700, from Rubiae Radix was studied using several murine experimental tumor systems. In P388 leukemia (inoculated intraperitoneally (i.p.), administered i.p.: i.p.-i.p.) the maximal increase in life span (ILSmax) resulting from an administration of RA-700 (4 mg/kg/d for 9 d) was 134% and the… (More)


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