A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.

@article{Olie2000ANA,
  title={A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.},
  author={Robert A. Olie and Ana Paula Sim{\~o}es-W{\"u}st and Bernd Baumann and Si{\^a}n H. Leech and Doriano Fabbro and Rolf Arno Stahel and Uwe Zangemeister-Wittke},
  journal={Cancer research},
  year={2000},
  volume={60 11},
  pages={
          2805-9
        }
}
Survivin, an inhibitor of apoptosis protein, deserves attention as a selective target for cancer therapy because it lacks expression in differentiated adult tissues but is expressed in a variety of human tumors. We designed 20-mer phosphorothioate antisense oligonucleotides targeting different regions of survivin mRNA and investigated their ability to down-regulate survivin mRNA and induce apoptosis in the lung adenocarcinoma cell line A549. Oligonucleotide 4003, which targets nucleotides 23… CONTINUE READING

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