A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells.

@article{Yamanaka2005ANA,
  title={A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells.},
  author={Kazuki Yamanaka and Palma Rocchi and Hideaki Miyake and Ladan Fazli and Bob Vessella and Uwe Zangemeister-Wittke and Martin E. Gleave},
  journal={Molecular cancer therapeutics},
  year={2005},
  volume={4 11},
  pages={1689-98}
}
Bcl-2 and Bcl-xL are associated with treatment resistance and progression in many cancers, including prostate cancer. The objective of this study was to determine whether a novel bispecific antisense oligonucleotide targeting both Bcl-2 and Bcl-xL induces apoptosis and enhances chemosensitivity in androgen-independent PC3 prostate cancer cells. An antisense oligonucleotide with complete sequence identity to Bcl-2 and three-base mismatches to Bcl-xL selected from five antisense oligonucleotides… CONTINUE READING
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