A novel antidiabetic therapy: free fatty acid receptors as potential drug target.

@article{Sekiguchi2015ANA,
  title={A novel antidiabetic therapy: free fatty acid receptors as potential drug target.},
  author={Hiroki Sekiguchi and Mayu Kasubuchi and Sae Hasegawa and Nicolas Pelisch and Ikuo Kimura and Atsuhiko Ichimura},
  journal={Current diabetes reviews},
  year={2015},
  volume={11 2},
  pages={107-15}
}
Excessive dietary intake of fat is strongly involved in the development of type 2 diabetes (T2D). Free fatty acids (FFAs), which are provided from dietary fat, are not only important nutrients, but also act as signaling molecules and stimulate key biological functions. Recent physiological and pharmacological studies have shown that several G-protein coupled receptors, such as FFAR1-4, are receptors for FFAs. FFAR1 and FFAR4 are activated by medium- and long-chain fatty acids, whereas FFAR2 and… CONTINUE READING