A novel anti-ulcer agent (TEI-5103) acting directly on the gastric mucosa from lumen. II: Distribution of TEI-5103 to gastric mucosa in rats

@article{Tanabe1988ANA,
  title={A novel anti-ulcer agent (TEI-5103) acting directly on the gastric mucosa from lumen. II: Distribution of TEI-5103 to gastric mucosa in rats},
  author={H Tanabe and Noboru Yamazaki and Jun-ichi Sato and Tsutomu Mochizuki and Kouichiro Okabe and Takeo Ohba and Tatsuyuki Naruchi},
  journal={Drug Metabolism and Pharmacokinetics},
  year={1988},
  volume={3},
  pages={33-40}
}
In the present study, we examined the distribution of TEI-5103 to gastric mucosa, as a target tissue, from the gastric lumen after oral administration of 14C-TEI-5103 to rats at its anti-ulcer dose (200 mg/kg). When given orally, the radioactivity in gastric mucosa was much higher than that in plasma, unlike after intraduodenal administration. And the radioactivity in gastric mucosa was mostly present as unchanged drug, which was different from that in plasma. The concentration of unchanged… 
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Figures and Tables from this paper

Distribution of Itopride Hydrochloride in Rat Gastric Muscular Layer—Quantitative Analysis Using Radioluminography—
TLDR
The results suggest that 14C-itopride hydrochloride is distributed to the gastric muscular layer via blood after being absorbed from small intestine, and indicates that the distribution of itopride in the gastrics muscular layer is good enough to explain its pharmacological effect.

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TLDR
Results indicate that TEI-5103 is effective as an anti-ulcer agent increasing gastric mucosal blood flow and possibly promoting the healing process of peptic ulcers.
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It is indicated that TEI-5103 increases GMBF by acting directly on the gastric microcirculation and that this increasing effect may contribute to the anti-ulcer activity of TEI -5103.
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TLDR
It is suggested that TEI-5103 has a cytoprotective effect like prostaglandin and promotes the integrity of the mucosal barrier and may contribute to its overall anti-ulcer effect.
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