A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis

@inproceedings{Boilard2010ANA,
  title={A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis},
  author={Eric Boilard and Ying Rong Lai and Katherine S. Larabee and Barbara Balestrieri and Farideh Ghomashchi and Daisuke Fujioka and Reuben G Gobezie and Jonathan S. Coblyn and Michael E. Weinblatt and Elena M. Massarotti and Thomas S. Thornhill and Maziar Divangahi and Heinz Remold and G{\'e}rard Lambeau and Michael H. Gelb and Jonathan P. Arm and David M Lee},
  booktitle={EMBO molecular medicine},
  year={2010}
}
Phospholipase A2 (PLA2) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA2 enzymes (sPLA2), numbering nine members in humans, are poorly understood, though they have been shown to participate in lipid mediator generation and the associated inflammation. To further understand the roles of sPLA2 in disease, we quantified the expression of these enzymes in the synovial… CONTINUE READING