A novel anti-HIV active integrase inhibitor with a favorable in vitro cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase metabolism profile.

@article{Okello2013ANA,
  title={A novel anti-HIV active integrase inhibitor with a favorable in vitro cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase metabolism profile.},
  author={Maurice O Okello and Sanjay Mishra and Malik Nishonov and Marie K. Mankowski and Julie D Russell and Jiayi Wei and Priscilla A. Hogan and Roger G. Ptak and Vasu Nair},
  journal={Antiviral research},
  year={2013},
  volume={98 3},
  pages={
          365-72
        }
}
Research efforts on the human immunodeficiency virus (HIV) integrase have resulted in two approved drugs. However, co-infection of HIV with Mycobacterium tuberculosis and other microbial and viral agents has introduced added complications to this pandemic, requiring favorable drug-drug interaction profiles for antiviral therapeutics targeting HIV. Cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT) are pivotal determining factors in the occurrence of adverse drug-drug… CONTINUE READING
BETA

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

365–372 G-6-PDH: glucose-6-phosphate dehydrogenase NMR: nuclear magnetic resonance gCOSY: gradient correlation spectroscopy HSQC: heteronuclear single quantum coherence

M. O. Okello
  • Antiviral Research
  • 2013

Similar Papers

Loading similar papers…