A novel anti‐apoptotic role for apolipoprotein L2 in IFN‐γ‐induced cytotoxicity in human bronchial epithelial cells

@article{Liao2011ANA,
  title={A novel anti‐apoptotic role for apolipoprotein L2 in IFN‐$\gamma$‐induced cytotoxicity in human bronchial epithelial cells},
  author={Wupeng Liao and Fera Yiqian Goh and Richard J Betts and David M Kemeny and John Kit Chung Tam and Boon Huat Bay and W S Fred Wong},
  journal={Journal of Cellular Physiology},
  year={2011},
  volume={226}
}
Airway epithelium functions not only as a physical barrier, but also a regulator of lung inflammation. IFN‐γ plays a critical role in airway inflammation associated with respiratory viral infection. We investigated differential protein profiling in IFN‐γ‐stimulated normal human bronchial epithelial cells (HBEC) using a 2‐dimensional gel electrophoresis followed by MALDI‐TOF‐MS/MS. IFN‐γ markedly stimulated apolipoprotein L2 (ApoL2) protein expression in normal HBEC. ApoL2 mRNA expression was… 
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