A novel anti‐apoptotic role for apolipoprotein L2 in IFN‐γ‐induced cytotoxicity in human bronchial epithelial cells

@article{Liao2011ANA,
  title={A novel anti‐apoptotic role for apolipoprotein L2 in IFN‐$\gamma$‐induced cytotoxicity in human bronchial epithelial cells},
  author={Wupeng Liao and Fera Yiqian Goh and Richard J Betts and David M Kemeny and John Kit Chung Tam and Boon Huat Bay and W S Fred Wong},
  journal={Journal of Cellular Physiology},
  year={2011},
  volume={226}
}
Airway epithelium functions not only as a physical barrier, but also a regulator of lung inflammation. IFN‐γ plays a critical role in airway inflammation associated with respiratory viral infection. We investigated differential protein profiling in IFN‐γ‐stimulated normal human bronchial epithelial cells (HBEC) using a 2‐dimensional gel electrophoresis followed by MALDI‐TOF‐MS/MS. IFN‐γ markedly stimulated apolipoprotein L2 (ApoL2) protein expression in normal HBEC. ApoL2 mRNA expression was… 
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In an in-silico screening to discover novel putative BH3-only proteins, this work identified yet another member of the apolipoprotein L family, apoL2 (ApoL2), as a BH 3 motif-containing protein, which, in contrast to what has been described about its homologs ApoL1 and Apo l6, did not regulate autophagy.
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Examination of the affected genes identified previously undetected and clinically significant pathways downstream of STAT3 that drive oncogenesis, and novel treatments aimed at these pathways may increase the survivability of activated B-cell−like diffuse large B- cell lymphoma.
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