A novel anti‐apoptotic role for apolipoprotein L2 in IFN‐γ‐induced cytotoxicity in human bronchial epithelial cells

@article{Liao2011ANA,
  title={A novel anti‐apoptotic role for apolipoprotein L2 in IFN‐$\gamma$‐induced cytotoxicity in human bronchial epithelial cells},
  author={Wupeng Liao and Fera Yiqian Goh and Richard J Betts and David M Kemeny and John Kit Chung Tam and Boon Huat Bay and W S Fred Wong},
  journal={Journal of Cellular Physiology},
  year={2011},
  volume={226}
}
Airway epithelium functions not only as a physical barrier, but also a regulator of lung inflammation. IFN‐γ plays a critical role in airway inflammation associated with respiratory viral infection. We investigated differential protein profiling in IFN‐γ‐stimulated normal human bronchial epithelial cells (HBEC) using a 2‐dimensional gel electrophoresis followed by MALDI‐TOF‐MS/MS. IFN‐γ markedly stimulated apolipoprotein L2 (ApoL2) protein expression in normal HBEC. ApoL2 mRNA expression was… 
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Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells
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It is proposed that ApoLs are involved in cell death linked to activation of DCs by viral stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C).
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It is demonstrated that prior CS exposure caused a biphasic T cell and IFN-γ response to subsequent infection with influenza in the lung, and the result suggested that CS affected the kinetics of the T cell response to IAV, which was suppressed at an early stage and exaggerated at a later stage.
Cell cycle regulation by glucosamine in human pulmonary epithelial cells.
Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway.
Mitochondrial proteomic analysis of human host cells infected with H3N2 swine influenza virus.
Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein
TLDR
In an in-silico screening to discover novel putative BH3-only proteins, this work identified yet another member of the apolipoprotein L family, apoL2 (ApoL2), as a BH 3 motif-containing protein, which, in contrast to what has been described about its homologs ApoL1 and Apo l6, did not regulate autophagy.
STAT3 Targets Suggest Mechanisms of Aggressive Tumorigenesis in Diffuse Large B-Cell Lymphoma
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Examination of the affected genes identified previously undetected and clinically significant pathways downstream of STAT3 that drive oncogenesis, and novel treatments aimed at these pathways may increase the survivability of activated B-cell−like diffuse large B- cell lymphoma.
ApolipoproteinL1 is expressed in papillary thyroid carcinomas.
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