A novel animal model of acute cochlear mitochondrial dysfunction.

@article{Hoya2004ANA,
  title={A novel animal model of acute cochlear mitochondrial dysfunction.},
  author={Noriyuki Hoya and Yasuhide Okamoto and Kazusaku Kamiya and Masato Fujii and Tatsuo Matsunaga},
  journal={Neuroreport},
  year={2004},
  volume={15 10},
  pages={1597-600}
}
Acute mitochondrial dysfunction in the cochlea is likely to result in hearing loss as a consequence of local energy shortage, similar to ischemia- or noise-induced hearing loss. To establish an animal model of acute cochlear mitochondrial dysfunction, we applied a mitochondrial toxin, 3-nitropropionic acid (3-NP) in the rat cochlea. Rats treated with 500mM 3-NP exhibited permanent threshold shifts in acoustic brainstem response while the same volume of 300mM 3-NP caused temporary threshold… CONTINUE READING