A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.

@article{Heeschen2002ANA,
  title={A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.},
  author={Christopher Heeschen and Michael Weis and Alexandra Aicher and Stefanie Dimmeler and John P Cooke},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 4},
  pages={527-36}
}
We have recently reported that nicotine has angiogenic effects, which appear to be mediated through non-neuronal nicotinic acetylcholine receptors (nAChRs). Here, we describe the endogenous cholinergic pathway for angiogenesis. In an in vitro angiogenesis model, increasing concentrations of the nonselective nAChR antagonist mecamylamine completely and reversibly inhibited endothelial network formation. Although several nAChR isoforms are expressed on endothelial cells (ECs), a similar… CONTINUE READING
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