A novel analog of TRH, YM14673, causes a decrease in brain TRH receptors in vitro.

@article{Monden1995ANA,
  title={A novel analog of TRH, YM14673, causes a decrease in brain TRH receptors in vitro.},
  author={Tsuyoshi Monden and Haruo Mizuma and Masanobu Yamada and Masami Murakami and Masaaki Mori},
  journal={Endocrine research},
  year={1995},
  volume={21 4},
  pages={803-14}
}
Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined. We tested effects of YM14673, a novel analog of TRH, on TRH receptors in rat brains in vitro. No significant binding of [3H]YM14673 to brain plasma membranes occurred. In contrast, preincubation of… CONTINUE READING