A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells.

  title={A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells.},
  author={Q. He and D Z Jiang},
  journal={Leukemia research},
  volume={23 4},
  • Q. He, D. Jiang
  • Published 1 April 1999
  • Biology, Chemistry
  • Leukemia research
A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells
The findings suggest that RM reduces HL-60 cells survival through a caspase-dependent death receptor pathway.
Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines
Information gathered suggests that this family of aminosteroids induced growth inhibition cells by arresting the cell cycle and triggering apoptosis, and showed weak toxicity on normal cell lines.
Methylprednisolone Induce Terminal Differentiation in the U-937 Human Myelomonocytic Leukemia Cells
It was observed that the significant terminal differentiation of U-937 cells occured after treatment with high dose (10-3 M) MP for 24 and 48 hrs, which points out that MP is a differentiation inducing agent for myelomonocytic leukemic cells and could be potential treating compound in other type ofLeukemic cell differentiation.
Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells
The results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.
Étude de l'activité biologique et du mécanisme d'action de dérivés stéroïdiens à potentiel anticancéreux
Information gathered suggests that this family of aminosteroids induced growth inhibition of HL-60 cells through arresting the cell cycle and triggering apoptosis, which encouraged us to further investigate the mechanisms underlying their selective-cytotoxicity.
Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes
It is observed that the amide coupling functionality gave stronger cytotoxic activity compared to the corresponding sulfonamides or benzylamines.


Microtiter assay useful for screening of cell-differentiation agents.
A microtiter assay that assesses differentiation of HL-60 cells on the basis of cytochrome c reduction is developed and confirmed by morphological assessment and by flow cytometric analysis of the DNA cell-cycle distribution and the cell-surface transferrin receptor.
Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.
  • J. Lotem, L. Sachs
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1979
It is suggested that TPA may act as a tumor promoter by increasing cell multiplication in initiated cells, induce differentiation in some cells, or inhibit differentiation in other cells, depending on which molecules are being regulated in the TPA-treated cells.
Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.
The marked similarity in behavior of HL-60 cells and Friend cells in the presence of these inducing agents suggests that similar molecular mechanisms are involved in the induction of differentiation of these human myeloid and murine erythroid leukemic cells.
[Synthesis of 2 beta-(4'-methyl-1'-piperazino)-3 alpha-hydroxyl-16,17- substituted-5 alpha-androstanes].
  • Q. He, Y. Xu
  • Chemistry, Biology
    Yao xue xue bao = Acta pharmaceutica Sinica
  • 1992
Preliminary results of biological experiment showed that the vicinal amino-alcohol compounds of 5 alpha-androstane possess to a different extent antiarrhythmic activities among which compounds VI, XI and XIV showed higher activities than others.
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture
The derivation from myeloid leukaemic cells of a leukocyte culture is described here for the first time that by morphological and histochemical criteria clearly and persistently differentiates along the myeloids series without an exogenous source of conditioned medium.
ORG 6001 (3α‐amino‐5α‐androstan‐2β‐ol‐17‐one hydrochloride), a steroidal anti‐arrhythmic agent
Org 6001 (3a-amino-5a-androstan-2fl-ol-17-one-hydrochloride; I) a nonhormonal amino steroid whose pharmacological profile is now presented is presented.