A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells.

@article{He1999ANA,
  title={A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells.},
  author={Q. He and D Z Jiang},
  journal={Leukemia research},
  year={1999},
  volume={23 4},
  pages={
          369-72
        }
}
  • Q. He, D. Jiang
  • Published 1 April 1999
  • Biology, Chemistry
  • Leukemia research
A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells
TLDR
The findings suggest that RM reduces HL-60 cells survival through a caspase-dependent death receptor pathway.
Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines
TLDR
Information gathered suggests that this family of aminosteroids induced growth inhibition cells by arresting the cell cycle and triggering apoptosis, and showed weak toxicity on normal cell lines.
Methylprednisolone Induce Terminal Differentiation in the U-937 Human Myelomonocytic Leukemia Cells
TLDR
It was observed that the significant terminal differentiation of U-937 cells occured after treatment with high dose (10-3 M) MP for 24 and 48 hrs, which points out that MP is a differentiation inducing agent for myelomonocytic leukemic cells and could be potential treating compound in other type ofLeukemic cell differentiation.
Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells
TLDR
The results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.
Étude de l'activité biologique et du mécanisme d'action de dérivés stéroïdiens à potentiel anticancéreux
TLDR
Information gathered suggests that this family of aminosteroids induced growth inhibition of HL-60 cells through arresting the cell cycle and triggering apoptosis, which encouraged us to further investigate the mechanisms underlying their selective-cytotoxicity.
Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes
TLDR
It is observed that the amide coupling functionality gave stronger cytotoxic activity compared to the corresponding sulfonamides or benzylamines.
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