A novel amino acid substitution in a voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti.

@article{Chang2009ANA,
  title={A novel amino acid substitution in a voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti.},
  author={Cheng Chang and Wen-Kai Shen and Tzu-Ting Wang and Ying-Hsi Lin and Err-lieh Hsu and Shu-Mei Dai},
  journal={Insect biochemistry and molecular biology},
  year={2009},
  volume={39 4},
  pages={272-8}
}
To identify pertinent mutations associated with knockdown resistance to permethrin, the entire coding sequence of the voltage-gated sodium channel gene Aa-para was sequenced and analyzed from a Per-R strain with 190-fold resistance to permethrin and two susceptible strains of Aedes aegypti. The longest transcript, a 6441bp open reading frame, encodes 2147 amino acid residues with an estimated molecular mass of 241kDa. A total of 33 exons were found in the Aa-para gene over 293kb of genomic DNA… CONTINUE READING
31 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Insecticide resistance in Aedes aegypti during dengue epidemics in Taiwan

  • Y. H. Lin, H. J. Teng, C. M. Ho, H. H. Pai, S. C. Wu, E. L. Hsu
  • Formosan Entomol
  • 2003
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…