A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997–1998 season in Tokyo

@article{Mori1999ANA,
  title={A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997–1998 season in Tokyo},
  author={S.-I. Mori and Mami Nagashima and Yuko Sasaki and Koh-ichiro Mori and Yukiko Tabei and Yu Yoshida and Kiyoshi Yamazaki and Ichiro Hirata and Hiromi Sekine and Takuya Ito and Shota Suzuki},
  journal={Archives of Virology},
  year={1999},
  volume={144},
  pages={147-155}
}
We analyzed the hemagglutinin (HA) genes of influenza A viruses consisting of 6 strains isolated from cerebrospinal fluids of patients with encephalopathy and 3 isolates from throat washes of patients without central nervous system symptoms during the 1997–1998 season in Tokyo. Aligned 9 amino acid sequences showed 7 common substitutions compared with A/Wuhan/359/95 (vaccine strain used in the season in Japan), which were allocated to three different antigenic sites on the H3 HA molecule. It is… CONTINUE READING

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