A novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs.

@article{Pagel1998ANA,
  title={A novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs.},
  author={P S Pagel and Lester T. Proctor and A Devcic and Douglas A. Hettrick and Judy R. Kersten and John P. Tessmer and Neil E. Farber and William T Schmeling and David C. Warltier},
  journal={Journal of cardiothoracic and vascular anesthesia},
  year={1998},
  volume={12 4},
  pages={429-34}
}
OBJECTIVES To test the hypothesis that L-659,066, a peripherally acting alpha 2-adrenoceptor agonist, will abolish the early pressor response but preserve the late depressor action of intravenous dexmedetomidine in conscious, unsedated dogs. DESIGN A prospective investigation. SETTING A laboratory research. PARTICIPANTS Nine chronically instrumented dogs. INTERVENTIONS Dogs received dexmedetomidine, 5 micrograms/kg intravenously, in the presence or absence of L-659,066, 0.1, 0.2, or 0.4… CONTINUE READING

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