A novel allele of HAP1 causes uninducible expression of HEM13 in Saccharomyces cerevisiae.

@article{Ushinsky1994ANA,
  title={A novel allele of HAP1 causes uninducible expression of HEM13 in Saccharomyces cerevisiae.},
  author={Sophia Ushinsky and Teresa Keng},
  journal={Genetics},
  year={1994},
  volume={136 3},
  pages={
          819-31
        }
}
Transcription of HEM13 in Saccharomyces cerevisiae is repressed by heme and oxygen. We have isolated two mutants in which expression of HEM13 is aberrant. The mutant alleles in these strains represent two different alleles of HAP1. HAP1 encodes an activator protein whose DNA binding activity is stimulated by heme, and is required for the transcription of CYC1, ROX1 and a number of other heme-dependent genes. One of our mutant alleles confers a phenotype much like that of the hap1::LEU2 allele… CONTINUE READING

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Multiple domains mediate heme control of the yeast activator HAP1

  • Molecular and General Genetics MGG
  • 1995
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