A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice

Abstract

Normal fusion of developing eyelids requires coordination of inductive signals from the eyelid mesenchyme with migration of the periderm cell layer and constriction of the eyelids across the eye. Failure of this process results in an eyelids open at birth (EOB) phenotype in mice. We have identified a novel spontaneous allele of Alx4 that displays EOB, in… (More)
DOI: 10.1007/s00335-015-9557-z

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