A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling

@article{Holmes2021ANA,
  title={A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling},
  author={Danalyn R. Holmes and Melissa Bredow and Kathrin Thor and Sydney A. Pascetta and Irina Sementchoukova and Kristen R. Siegel and Cyril Zipfel and Jacqueline Monaghan},
  journal={bioRxiv},
  year={2021}
}
Immune recognition in plants is governed by two major classes of receptors: pattern recognition receptors (PRRs) and nucleotide-binding leucine-rich repeat receptors (NLRs). Located at the cell surface, PRRs bind extracellular ligands originating from microbes (indicative of ‘non-self’) or damaged plant cells (indicative of ‘infected-self’), and trigger signaling cascades to protect against infection. Located intracellularly, NLRs sense pathogen-induced physiological changes and trigger… 
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