A novel affinity-based controlled release system involving derivatives of dextran with enhanced osmotic activity.

Dextran is a highly biocompatible molecule with osmotic activity. We synthesized histidine derivatives of dextran, DexH (dextran histidine), to test the feasibility of an IMAC-based controlled release system. DexH was synthesized by the periodate oxidation method. The effect of periodate oxidation and histidine conjugation on osmotic activity was tested… CONTINUE READING