A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

Abstract

Voltage-gated Na(+) channels (VGSCs), predominantly the 'neonatal' splice form of Na(v)1.5 (nNa(v)1.5), are upregulated in metastatic breast cancer (BCa) and potentiate metastatic cell behaviours. VGSCs comprise one pore-forming alpha subunit and one or more beta subunits. The latter modulate VGSC expression and gating, and can function as cell adhesion… (More)
DOI: 10.1016/j.biocel.2008.11.001

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Cite this paper

@article{Chioni2009ANA, title={A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.}, author={Athina-Myrto Chioni and William J Brackenbury and Jeffrey D. Calhoun and Lori L Isom and Mustafa B. A. Djamgoz}, journal={The international journal of biochemistry & cell biology}, year={2009}, volume={41 5}, pages={1216-27} }