A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

  title={A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms},
  author={Timothy W. Lovenberg and Bruce M. Baron and Luis de Lecea and Joseph D. Miller and Rebecca A Prosser and Michael A. Rea and Pamela E. Foye and Margaret M. Racke and Amy L. Slone and Barry W. Siegel and Patria E. Danielson and J. Gregor Sutcliffe and Mark G Erlander},

Cellular mechanisms of the 5-HT7 receptor-mediated signaling

The 5-HT7 receptor is coupled to the stimulatory Gs-protein, and receptor stimulation results in activation of adenylyl cyclase (AC) leading to a rise of cAMP concentration, andThis review focuses on molecular mechanisms responsible for the 5- HT7 receptor-mediated signaling.

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

Molecular biology of 5-HT receptors

Presence of a 5-HT7 receptor positively coupled to adenylate cyclase activation in human granulosa-lutein cells.

It is reported here that 5-HT receptors in these cells are positively coupled to adenylate cyclase activity and implicated in the heterologous down-regulation hCG-stimulated cAMP response in hGLC, with a possible ramification for luteal insufficiency.

Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland.

Correlation analysis between the potencies of the different compounds in the model and those previously reported for various recombinant 5-HT receptors showed that the rat adrenal 5- HT receptor exhibits the same pharmacological profile as the5-HT(7) receptor transiently expressed in COS-7 cells.



Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.

A complementary DNA clone containing the coding sequence of one of these rapidly responding channels, a 5HT3 subtype of the serotonin receptor, has been isolated by screening a neuroblastoma expression library for functional expression of serotonin-gated currents in Xenopus oocytes.

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor.

In situ hybridization and RNA blot analysis indicate that the 5HTlc receptor is expressed in neurons in many regions of the central nervous system and suggest that this subclass of receptor may mediate many of thecentral actions of serotonin.

Serotonin and the Mammalian Circadian System: I. In Vitro Phase Shifts by Serotonergic Agonists and Antagonists

The results suggest that the 5-HT-ergic input from the raphe nuclei can modulate the phase of the SCN circadian clock, and hypothesize that the nighttime5-HT receptor is a 5- HT1-like receptor.

Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase.

The predicted structure of the 5HT-dro receptor reveals two unusual features: eight putative transmembrane domains instead of the expected seven and a Gly-Ser repeat that is a potential glycosaminoglycan attachment site.

A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns.

The 5HT‐dro2A receptor is predominantly expressed in midline motor neurons (VUM neurons) that innervate larval muscles thus suggesting a role for this receptor in motor control.

Structure and functional expression of cloned rat serotonin 5HT‐2 receptor.

A complementary DNA (cDNA) encoding a serotonin receptor with 51% sequence identity to the 5HT‐1C subtype was isolated from a rat brain cDNA library by homology screening. Transient expression of the

The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.

The results demonstrate that the 5HT1D receptors constitute a heterogeneous family of receptors with distinct intracellular signalling properties and expression patterns, and are a distant relative of all previously identified 5‐HT receptors.

A serotonin agonist phase-shifts the circadian clock in the suprachiasmatic nuclei in vitro