A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

@article{Lovenberg1993ANA,
  title={A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms},
  author={Timothy W. Lovenberg and Bruce M. Baron and Luis de Lecea and Joseph D. Miller and Rebecca A Prosser and Michael A. Rea and Pamela E. Foye and Margaret M. Racke and Amy L. Slone and Barry W. Siegel and Patria E. Danielson and J. Gregor Sutcliffe and Mark G. Erlander},
  journal={Neuron},
  year={1993},
  volume={11},
  pages={449-458}
}
We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT7, which is coupled to the stimulation of adenylyl cyclase. 5-HT7 mRNA is expressed discretely throughout the CNS, predominantly in the thalamus and hypothalamus. 5-HT7 has a unique pharmacological profile that redefines agonist and antagonist classification of ligands previously thought to be "selective." The circadian phase of spontaneous neuronal activity of the rat suprachiasmatic nucleus of the… Expand
Cellular mechanisms of the 5-HT7 receptor-mediated signaling
TLDR
The 5-HT7 receptor is coupled to the stimulatory Gs-protein, and receptor stimulation results in activation of adenylyl cyclase (AC) leading to a rise of cAMP concentration, andThis review focuses on molecular mechanisms responsible for the 5- HT7 receptor-mediated signaling. Expand
5-HT4, 5-HT6, 5-HT7; molecular pharmacology of adenylate cyclase stimulating receptors
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The most recent subset of receptors for serotonin to be cloned are those that couple to the stimulation of adenylate cyclase activity, and these subtypes, although sharing a common signal transduction pathway, are remarkably divergent in their amino acid sequences, distribution in the brain and pharmacological properties. Expand
Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus
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It is shown that several agents administered in a profile consistent with activity at the 5-HT7 receptor produce significant functional Fos immunoreactivity in the suprachiasmatic nucleus (SCN), an effect reduced upon chronic exposure. Expand
Localization of serotonin5A receptors in discrete regions of the circadian timing system in the Syrian hamster
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The 5-HT(5A) receptors are localized within several important neuroanatomical substrates of the circadian timekeeping system, and within the raphe nuclei, appear to be present on serotonin neurons. Expand
Molecular biology of 5-HT receptors
TLDR
Evidence for an even greater degree of operational diversity is supported by the existence of a great number of splice and editing variants for several 5-HT receptors, their possible modulation by accessory proteins and chaperones, as well as their potential to form homo or heteromers both at the GPCR and at the ligand-gated channel level. Expand
Immunohistochemical localization of serotonin receptors in the rat suprachiasmatic nucleus
TLDR
The present study uses immunohistochemistry to examine the presence of three different 5-HT receptor subtypes in the suprachiasmatic nucleus in male albino Wistar rats and shows that serotonin acting through the 5- HT2c receptor subtype may be important in the phase shifting effects of light on the circadian system. Expand
Presence of a 5-HT7 receptor positively coupled to adenylate cyclase activation in human granulosa-lutein cells.
TLDR
It is reported here that 5-HT receptors in these cells are positively coupled to adenylate cyclase activity and implicated in the heterologous down-regulation hCG-stimulated cAMP response in hGLC, with a possible ramification for luteal insufficiency. Expand
Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland.
TLDR
Correlation analysis between the potencies of the different compounds in the model and those previously reported for various recombinant 5-HT receptors showed that the rat adrenal 5- HT receptor exhibits the same pharmacological profile as the5-HT(7) receptor transiently expressed in COS-7 cells. Expand
Human serotonin 5‐HT7 receptor: cloning and pharmacological characterisation of two receptor variants
TLDR
It is suggested that both splice variants of the 5‐HT7 receptor identified in human brain that differ in the lengths of their intracellular carboxy terminal tail are derived from a single gene by alternative mRNA splicing. Expand
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