A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

@article{Lovenberg1993ANA,
  title={A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms},
  author={Timothy W. Lovenberg and Bruce M. Baron and Luis de Lecea and Joseph D. Miller and Rebecca A Prosser and Michael A. Rea and Pamela E. Foye and Margaret M. Racke and Amy L. Slone and Barry W. Siegel and Patria E. Danielson and J. Gregor Sutcliffe and Mark G Erlander},
  journal={Neuron},
  year={1993},
  volume={11},
  pages={449-458}
}

Cellular mechanisms of the 5-HT7 receptor-mediated signaling

The 5-HT7 receptor is coupled to the stimulatory Gs-protein, and receptor stimulation results in activation of adenylyl cyclase (AC) leading to a rise of cAMP concentration, andThis review focuses on molecular mechanisms responsible for the 5- HT7 receptor-mediated signaling.

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

Molecular biology of 5-HT receptors

Presence of a 5-HT7 receptor positively coupled to adenylate cyclase activation in human granulosa-lutein cells.

It is reported here that 5-HT receptors in these cells are positively coupled to adenylate cyclase activity and implicated in the heterologous down-regulation hCG-stimulated cAMP response in hGLC, with a possible ramification for luteal insufficiency.

Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland.

Correlation analysis between the potencies of the different compounds in the model and those previously reported for various recombinant 5-HT receptors showed that the rat adrenal 5- HT receptor exhibits the same pharmacological profile as the5-HT(7) receptor transiently expressed in COS-7 cells.
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