A novel adenovirus expressing human 4–1BB ligand enhances antitumor immunity

4–1BB ligand (4–1BBL), a member of the tumor necrosis factor (TNF) superfamily, interacts with 4–1BB (CDw137) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth. Various studies have demonstrated a role for murine 4–1BB in immune function, but relatively few investigations of human 4–1BB have been conducted… (More)