A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice.

Abstract

Although the brain functions of specific acetyltransferases such as the CREB-binding protein (CBP) and p300 have been well documented using mutant transgenic mice models, studies based on their direct pharmacological activation are still missing due to the lack of cell-permeable activators. Here we present a small-molecule (TTK21) activator of the histone… (More)
DOI: 10.1523/JNEUROSCI.5772-12.2013

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