A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation

@article{Yang1988ANA,
  title={A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation},
  author={Soo Young Yang and Stephen Denning and Shigeki Mizuno and Bryony Dupont and Barton F Haynes},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={168},
  pages={1457 - 1468}
}
Prior studies have shown that thymocytes, unlike peripheral T cells, do not proliferate in response to mitogenic combinations of anti-CD2 mAbs. The present study demonstrated that stimulation by a mitogenic anti-CD2 combination (9-1 plus 9.6) with anti-CD28 induced vigorous thymocyte proliferation in the absence of exogenous IL-2. This thymocyte proliferation was IL-2 dependent as shown by the complete inhibition using anti-IL-2-R mAbs. Induction of IL-2-R transcripts was detected in thymocytes… CONTINUE READING
Highly Cited
This paper has 114 citations. REVIEW CITATIONS

Citations

Publications citing this paper.

114 Citations

0204060'89'95'02'09'16
Citations per Year
Semantic Scholar estimates that this publication has 114 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…