A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans

@article{Croce2004ANA,
  title={A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans},
  author={Assunta Croce and Giuseppe Cassata and Andrea Disanza and Maria Cristina Gagliani and Carlo Tacchetti and Maria Grazia Malabarba and M Carlier and Giorgio Scita and Ralf Baumeister and Pier Paolo Di Fiore},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1173-1179}
}
Redundant gene function frequently hampers investigations of the physiological roles of mammalian proteins. This is the case for Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos1 (refs 2–5), thereby regulating actin remodelling by RTKs. EPS8-knockout mice, however, exhibit no evident phenotype, owing to the redundant function of three other EPS8-related genes. Here we show that in the nematode… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

interference in Caenorhabditis elegans

S. Confalonieri, A. E. Salcini, C. Puri, C. Tacchetti, P. P. Di Fiore
2001

Similar Papers

Loading similar papers…