A novel Wilms’ tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema

@article{Wagner2008ANW,
  title={A novel Wilms’ tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema},
  author={Nicole Wagner and Kay-Dietrich Wagner and Mickael Afanetti and Fabien Nevo and Corinne Antignac and Jean-François Michiels and Andreas Schedl and E Neidhardt Berard},
  journal={Pediatric Nephrology},
  year={2008},
  volume={23},
  pages={1445-1453}
}
The Wilms’ tumor suppressor gene WT1 is an important regulator of development. Mutations in this gene have been associated with Wilms’ tumor, Frasier syndrome, and Denys–Drash syndrome, as well as isolated glomerular disease. Here we report the case of a 4-month-old girl, who presented with end-stage renal disease, thrombopenia, anemia, and cardiac hypertrophy accompanied by severe hypertension. Histological analysis of kidney biopsies revealed a massive and diffuse nephroblastomatosis with a… CONTINUE READING
2 Extracted Citations
24 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 24 references

Similar Papers

Loading similar papers…