A novel USP apparatus 4 based release testing method for dispersed systems.

  title={A novel USP apparatus 4 based release testing method for dispersed systems.},
  author={Upkar Bhardwaj and Diane J. Burgess},
  journal={International journal of pharmaceutics},
  volume={388 1-2},
A novel dialysis adapter has been developed for USP apparatus 4 for in vitro release testing of dispersed system dosage forms. This USP apparatus 4 method was optimized and compared with currently used dialysis and reverse dialysis sac methods. Optimization studies for the USP apparatus 4 method showed that release from solution, suspension and liposome formulations was not flow rate limited and was not affected by change in the dialysis adapter sample volume from 250microl to 500microl. The… CONTINUE READING
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