A novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injury

@inproceedings{Gao2015ANT,
  title={A novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injury},
  author={Kun Gao and Yuan Chi and Xiling Zhang and Hui Zhang and Gang Li and Wei Sun and Masayuki Takeda and Jian Yao},
  booktitle={Journal of cellular and molecular medicine},
  year={2015}
}
Gap junctions (GJs) play an important role in the regulation of cell response to many drugs. However, little is known about their mechanisms. Using an in vitro model of cytotoxicity induced by geneticin (G418), we explored the potential signalling mechanisms involved. Incubation of cells with G418 resulted in cell death, as indicated by the change in cell morphology, loss of cell viability and activation of caspase-3. Before the onset of cell injury, G418 induced reactive oxygen species (ROS… CONTINUE READING
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