A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells.

@article{ErtongurFauth2014ANT,
  title={A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells.},
  author={Torsten Ertongur-Fauth and Andreas Hochheimer and Joerg M. Buescher and Stefan Rapprich and Michael Krohn},
  journal={Experimental dermatology},
  year={2014},
  volume={23 11},
  pages={825-31}
}
Sweating is an important physiological process to regulate body temperature in humans, and various disorders are associated with dysregulated sweat formation. Primary sweat secretion in human eccrine sweat glands involves Ca(2+) -activated Cl(-) channels (CaCC). Recently, members of the TMEM16 family were identified as CaCCs in various secretory epithelia; however, their molecular identity in sweat glands remained elusive. Here, we investigated the function of TMEM16A in sweat glands. Gene… CONTINUE READING