A novel T cell activation antigen identified by monoclonal IMN3.1 antibody and expressed preferentially on human T cells susceptible to apoptotic cell death.

@article{Uehara1993ANT,
  title={A novel T cell activation antigen identified by monoclonal IMN3.1 antibody and expressed preferentially on human T cells susceptible to apoptotic cell death.},
  author={Toshiki Uehara and Toshio Miyawaki and Shunnosuke Natsuume-Sakai and R Nibu and Masafumi Hasui and Akihiro Yachie and Shigeomi Shimizu and Nobuhiro Taniguchi},
  journal={Journal of immunology},
  year={1993},
  volume={150 8 Pt 1},
  pages={3243-53}
}
When cultured without appropriate growth factors, most of activated (CD45RO+) T cells expanded in acute EBV-induced infectious mononucleosis (IM) easily die via an apoptotic cell death mechanism, indicating one Ag-driven selection in the periphery. In this work, we attempted to raise the mAb against cell surface molecules, preferentially expressed on T cells entering apoptosis, by immunizing PBMC from an acute IM patient. We obtained one mAb, termed IMN3.1, that could define clearly the… CONTINUE READING